Evan Miller on an in his opinion obviously imminent future with big tablets as the form factor of choice for professionals, primarily focussing on the shortcomings of mouse pointers:

The mouse pointer was designed for a 9″ screen, not a 29″ one.

It’s an intriguing argument, especially the serious considerations of styli (cue “They blow it” quote from Steve Jobs). I think there could be something here. (Even if I have historically been swayed by Apple’s arguments about the tiring of arms, the angle at which you can use a Surface Studio should help with that.)